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[Surgical treatment of chronic recurrent pyogenes].
The treatment of chronic recurrent tonsillitis by tonsillectomy is well known. It is a widely accepted method, but this technique does not seem to be particularly effective in the treatment of chronic recurrent phlegmonous pyoderma. The aim of this study was to evaluate the changes in the “pathogenic role” of tonsils in the etiology of chronic recurrent pyoderma and the effectiveness of the surgical treatment of tonsils and tonsil tissues in the patients with this disease. The study was performed on 74 patients operated for chronic recurrent pyoderma in the Department of Otorhinolaryngology, Kazan Medical University, during the period from 1976 to 1992. All the patients were divided into two groups. In the first group 18 patients were operated with tonsillectomy and the rest of the patients were operated with external drainage of pyosis and excision of tonsillar tissues. The observations demonstrated a greater effectiveness of the first technique. The authors recommend this surgical treatment in acute and subacute forms of the disease.Description
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Nitric oxide synthase (NOS) catalyzes the conversion of the amino acid L-arginine to L-citrulline and the gas nitric oxide (NO). All three NOS isoforms, NOS1, NOS2, and NOS3, represent important targets for pharmacotherapy of cardiovascular and neurodegenerative diseases. Although the three isoforms show high similarity in structure and chemistry, the important differences in pharmacology, enzymatic characteristics, and inducibility have led to a lack of selective drugs for the individual NOS isoforms. This can be attributed to the fact that NOS shares the same reaction mechanism but differs in binding affinity for the cofactors and substrate of the different NOS isoforms. Significant effort has been invested in finding NOS selective drugs, but the results have been disappointing. Here, the coupling of NOS with cofactors and substrate at the level of the X-ray crystal structures is exploited to investigate the structural basis of the ligand-selectivity in each of the three NOS isoforms. Computational investigations of the binding modes of 15 known NOS active-site ligands were performed, revealing conformational differences in the ligand pocket with different ligand families. In addition
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